Is it genetically affected by cancer in smokers?

2018/09/28 14:29
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Is it genetically affected by cancer in smokers?
Smoking has been shown to have a serious impact on life and disease development. Many studies have suggested that smoking can increase mortality and increase the risk of cancer by accelerating the aging process. In reality, however, not all smokers have an early risk of death or cancer, and a small percentage of smokers live long. Genomic information from long-lived smokers is the subject of research. Researchers have found that combinations of specific types of single nucleotide polymorphisms (SNPs) allow some people to better protect against environmental damage and reduce harmful effects. The damage caused by chemicals has a longer life span and a lower incidence of cancer.
Researchers at the University of California, Los Angeles, published a report in The Journals of Gerontology, Series A: Biological Sciences & Medical Sciences, using the genomic information of long-term smokers to identify single-nucleotide polymorphisms associated with longevity in smoking. Sexual network. In these “special populations”, their genomes allow these people to better resist the harm the environment (such as smoking) causes to the body. Collectively, these single nucleotide polymorphisms are closely related to longevity (or low cancer rates).
The author of the article, Morgan E. Levine, said: "We have discovered a set of genetic markers (nucleotide polymorphisms SNPs) that together seem to promote longevity. More importantly, these nucleotide polymorphisms Many of the markers in the spots are important for the aging and life-related pathways found in animal models. There is evidence that the genes in which these single nucleotide polymorphisms are located may contribute to prolonging cell life. Increases cell protection and cell repair after injury. Therefore, even if some people are exposed to high levels of biological stress (such as various chemical molecules of cigarette smoke), cells in their bodies may still be well protected and repaired. mechanism."
This protective and repair mechanism may help cells maintain the stability of the cell's genome. Genomic instability is also one of the hallmarks of cancer, so the same (long-lived smoker) genetic combination can both promote the survival of smokers and help the body better fight cancer or reduce the incidence of cancer. This is consistent with the findings, as the “special” combination of genes in the long-lived smoker's genome detected by the study can lead to a 11% lower cancer incidence.
These findings suggest that longevity is not entirely determined by environmental factors. The longevity mechanism may also be associated with complex genetic networks at the cellular level. This genetically related genetic network may enhance the stress resistance of cells and the stability of the cellular genome (genetic material). Therefore, there is reason to believe that long-lived smokers represent a “special” group. Unique genetic material may enable them to better respond to the stresses and stresses of the environment.
(Qijian Bio-Biopharmaceutical)