3D printing pharmaceutical squeaky personality medical door
Imagine: One day you are sick, go to the hospital for diagnosis, the doctor will open a "barcode" prescription that is converted into a binary number after you see the symptoms. You take the prescription to print the medicine before the hospital self-service 3D printer, and then take the medicine. This seemingly inconceivable medical process is getting closer to reality today due to the development of 3D printing technology.
On August 5th, the first SPRITAM (levetiracetam) fast-dissolving tablet prepared by Aprecia Pharmaceuticals using 3D printing technology was approved by the US Food and Drug Administration (FDA) and will be officially sold in 2016. This means that 3D printing technology will further move into the pharmaceutical field after printing human organs, which is of great significance for the realization of precision pharmaceuticals and targeted pharmaceuticals in the future.
Experts from the Guangdong Pharmaceutical College believe that 3D printing pharmaceuticals have more precise characteristics and will complement traditional pharmaceuticals. In the future, the combination of Chinese medicine and this technology may also become a trend.
Instant dysphagia becomes the biggest beneficiary
It is understood that the approved "Lesilacetam Instant Tablet" is based on Aprecia's proprietary ZipDose3D printing technology. The produced tablets have a rich internal cavity and a very high internal surface area, so they can be quickly melted by a small amount of water in a short time. Such characteristics have brought good news to some patients with swallowing disorders.
This tablet will be used primarily to treat children and adults with epilepsy. According to the data, more than 3 million people in the United States suffer from active epilepsy each year, and more than 14% of them are children. A considerable number of patients often have a certain degree of swallowing disorders, often taking place such as vomiting and card medicine, affecting the exertion of the drug effect, and some children have fear and rejection of oral tablets and are unwilling to take the drugs on time. The tablet dissolves quickly with only one bite of water, greatly improving the comfort of oral medications, especially for patients who need to take large doses of drugs at once. This "fast-acting tablet" can greatly reduce their medication. pain.
The first 3D forming technology developed by the Massachusetts Institute of Technology (MIT) uses electrostatic ink nozzles to spray liquid binder onto the pre-paved powder layer in accordance with the cross-sectional shape of the part, so that some of the powders are bonded together to form a cross-sectional profile. After the formation of a layer of powder, a layer of powder is applied to bond the next layer of powder, and the cycle is followed by post-treatment to form a prototype.
Aprecia's ZipDose3D printing technology is a prototype that innovatively combines multiple layers of powdered agents with aqueous fluids to create a porous, water-soluble agent. The remarkable function of this method is that high-dose drugs are no longer used. Hard to swallow.
Customized drug accuracy is expected to improve
The introduction of Aprecia's SPRITAM tablets has greatly encouraged the use of 3D printing technology in the pharmaceutical industry. As early as 2013, Turkish industrial designer Ali Akay and Indian industrial designer Bharat Joshi proposed the idea of “on-demand pharmaceuticals” with 3D printers. By combining 3D technology with pharmaceutical technology, doctors converted prescription information into A binary barcode, a doctor or patient prints on demand on a 3D printer, how much is needed, and does not need to be printed.
This kind of idea is mainly aimed at the patient's demand for the quantity of drugs, which can effectively reduce the problems of a series of drugs caused by drug inventory and deterioration. In fact, the most important breakthrough in 3D printing drugs is the dream of further tailoring drugs for patients.
The traditional pharmaceutical process is to uniformly mix various raw materials, extrude and form into a general-purpose drug. This method of pharmacy accurately determines the parameters such as the size, shape and dosage of each tablet, and fixes these parameters and then performs large-scale production.
However, this fixed-dose tablet is not fully applicable because of the changing condition and the continual changes in the patient's constitution. It is often the case that doctors who have improved their condition will take the tablets into the original half and take them because they no longer need such large doses, but the method of manually opening the drugs does not guarantee the accuracy of the drug dose. . And 3D drugs can improve this situation, doctors can even prescribe drugs according to each person's body's metabolic rules and DNA characteristics, increase or decrease the drug solution when printing, and print out tailor-made drugs.
Future Chinese medicine or sparks with 3D printing
Yang Fan, deputy dean of the Pharmaceutical College of Guangdong Pharmaceutical University, believes that 3D printing pharmaceuticals and traditional pharmaceuticals are complementary, and the two are complementary. On the one hand, traditional pharmaceuticals have matured over a long period of time and have unique advantages in industrialization and scale. Traditional medicines are still the mainstream choice in the treatment of some common diseases. On the other hand, 3D printing medicine, as an emerging technology, can play an incomparable effect on traditional medicines in some special treatments.
She said that the biggest factor affecting 3D printing pharmacy is the regulation of drugs. Now that 3D printing technology is maturing, there are countless examples of successful medical use of this technology. But in the pharmaceutical field, the most difficult thing is how to strictly control and supervise the printing of pharmaceutical raw materials. At the same time, 3D printing pharmacy as a digital information-based technology will also put forward higher requirements for pharmaceutical talents. In the future, pharmaceutical pharmacists not only need to be proficient in pharmacy, but also need excellent 3D printing operation technology.
In general, the widespread use of 3D printing technology in medical treatment is an unstoppable trend. The popularity of 3D printing drugs and the implementation of personalized medicine are just around the corner. It is worth mentioning that the principle of 3D printing pharmaceuticals and Chinese traditional Chinese medicines based on the physical characteristics of each person is consistent. In the future, the use of 3D printing technology in traditional Chinese medicine may form another new development momentum.
(Qijian Bio, Biopharmaceutical www.qjbio.com.cn www.qijianbio.com)
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