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Cell: Breakthrough! Scientists identify key gene that is expected to promote cardiomyocyte regeneration to form heart tissue!

Cell: Breakthrough! Scientists identify key gene that is expected to promote cardiomyocyte regeneration to form heart tissue!

  • Categories:Industry news
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  • Time of issue:2018-09-28
  • Views:93

(Summary description)March 6, 2018 /Bio Valley BIOON/ -- Recently, in a study published in the international journal Cell, scientists from the Gladstone Institutes (Gladstone Institutes) A key gene for adult cell division and proliferation; some organisms have the ability to regenerate tissue remarkably. If fish and salamanders suffer heart damage, their cells will continue to divide and successfully repair damaged organs. Imagine if we also What would it be like to have this regenerative ability?

In the embryo, human heart cells can sort and proliferate to promote heart growth and development; but the problem is that right after birth, the body's cardiomyocytes lose the ability to divide, unlike many cells in other tissues of the body. The same, including the brain, spinal cord, and pancreas. Dr Deepak Srivastava explained that because many adult cells cannot divide, the body cannot replace the lost cells, which can lead to disease. If we can find a new way to make these cells divide again, then we may hope Achieving the regenerative capacity of a range of tissues.

Scientists have been trying to do this for decades, with little success; so far, these attempts have been ineffective and difficult to replicate; in this latest study, researchers may hope To achieve this ultimate goal, the researchers developed the first efficient and stable method to create adult cardiomyocytes that can divide and repair damaged heart tissue during a heart attack (at least in animal models). Of the more than 24 million patients with heart failure worldwide, there are few treatment options for patients other than heart transplants to treat patients with advanced disease; instead, cells divide to make new cardiomyocytes (similar to (like salamanders) may be able to help millions of patients repair damaged heart tissue.

Unlock the potential of adult cell reproduction

In this study, researchers Srivastava and colleagues identified four genes that control the cell division cycle. They found that when combined, these genes promote mature cardiomyocytes to re-enter the cell cycle, thereby causing Promotes cell division and rapid proliferation. "When the function of all four genes is increased simultaneously, adult cells begin to divide again and regenerate heart tissue," said researcher Tamer Mohamed. "We also found that when patients developed heart failure, combining these genes significantly improved the hearts of patients. Function.

The researchers then tested the new technique in animal models and in cardiomyocytes derived from human stem cells, using a rigorous technique to track whether these adult cells could actually make dividing cells that carry special colors that can be easily monitored. To divide in the heart, the results showed that in the mixed mode of the four genes, 15%-20% of the cardiomyocytes were able to divide and remain active.

Compared to previous findings (1%), this new technology may increase the efficiency and reliability of cell division. Of course, in human organs, gene application should be strictly monitored, because excessive or redundant cells Division often induces tumors; researchers will simplify the technique in later studies by finding ways to reduce the number of genes needed for cell division (while still maintaining the efficiency of cell division), and it turns out that using Two drug-like molecules to remove two of the genes yielded the same findings.

Regenerates a variety of human tissues

The researchers believe that this new technology may be used to induce other types of adult cells to divide again, and the four genes they used in the article are not unique to heart tissue; in the end, Srivastava said, heart cells are important to us. It's especially challenging because cardiomyocytes exit the cell cycle after an individual is born, and the cell's state is locked, which may explain why people don't develop heart tumors; The new technology for re-dividing these "difficult" cells may also be used in the future to "unlock" the potential of other types of cells to divide, including nerve cells, pancreatic cells, hair cells in the ear and retinal cells.

Based on the results of this paper, the researchers hope that through more in-depth research in the future, more powerful regenerative technologies can be developed to treat not only heart failure, but also many types of human diseases, including brain damage, diabetes, hearing loss and Blindness, etc.; researchers believe that the ability of human tissue to regenerate will one day surpass that of salamanders. (Qjbio qjbio.com.cn)

Cell: Breakthrough! Scientists identify key gene that is expected to promote cardiomyocyte regeneration to form heart tissue!

(Summary description)March 6, 2018 /Bio Valley BIOON/ -- Recently, in a study published in the international journal Cell, scientists from the Gladstone Institutes (Gladstone Institutes) A key gene for adult cell division and proliferation; some organisms have the ability to regenerate tissue remarkably. If fish and salamanders suffer heart damage, their cells will continue to divide and successfully repair damaged organs. Imagine if we also What would it be like to have this regenerative ability?

In the embryo, human heart cells can sort and proliferate to promote heart growth and development; but the problem is that right after birth, the body's cardiomyocytes lose the ability to divide, unlike many cells in other tissues of the body. The same, including the brain, spinal cord, and pancreas. Dr Deepak Srivastava explained that because many adult cells cannot divide, the body cannot replace the lost cells, which can lead to disease. If we can find a new way to make these cells divide again, then we may hope Achieving the regenerative capacity of a range of tissues.

Scientists have been trying to do this for decades, with little success; so far, these attempts have been ineffective and difficult to replicate; in this latest study, researchers may hope To achieve this ultimate goal, the researchers developed the first efficient and stable method to create adult cardiomyocytes that can divide and repair damaged heart tissue during a heart attack (at least in animal models). Of the more than 24 million patients with heart failure worldwide, there are few treatment options for patients other than heart transplants to treat patients with advanced disease; instead, cells divide to make new cardiomyocytes (similar to (like salamanders) may be able to help millions of patients repair damaged heart tissue.

Unlock the potential of adult cell reproduction

In this study, researchers Srivastava and colleagues identified four genes that control the cell division cycle. They found that when combined, these genes promote mature cardiomyocytes to re-enter the cell cycle, thereby causing Promotes cell division and rapid proliferation. "When the function of all four genes is increased simultaneously, adult cells begin to divide again and regenerate heart tissue," said researcher Tamer Mohamed. "We also found that when patients developed heart failure, combining these genes significantly improved the hearts of patients. Function.

The researchers then tested the new technique in animal models and in cardiomyocytes derived from human stem cells, using a rigorous technique to track whether these adult cells could actually make dividing cells that carry special colors that can be easily monitored. To divide in the heart, the results showed that in the mixed mode of the four genes, 15%-20% of the cardiomyocytes were able to divide and remain active.

Compared to previous findings (1%), this new technology may increase the efficiency and reliability of cell division. Of course, in human organs, gene application should be strictly monitored, because excessive or redundant cells Division often induces tumors; researchers will simplify the technique in later studies by finding ways to reduce the number of genes needed for cell division (while still maintaining the efficiency of cell division), and it turns out that using Two drug-like molecules to remove two of the genes yielded the same findings.

Regenerates a variety of human tissues

The researchers believe that this new technology may be used to induce other types of adult cells to divide again, and the four genes they used in the article are not unique to heart tissue; in the end, Srivastava said, heart cells are important to us. It's especially challenging because cardiomyocytes exit the cell cycle after an individual is born, and the cell's state is locked, which may explain why people don't develop heart tumors; The new technology for re-dividing these "difficult" cells may also be used in the future to "unlock" the potential of other types of cells to divide, including nerve cells, pancreatic cells, hair cells in the ear and retinal cells.

Based on the results of this paper, the researchers hope that through more in-depth research in the future, more powerful regenerative technologies can be developed to treat not only heart failure, but also many types of human diseases, including brain damage, diabetes, hearing loss and Blindness, etc.; researchers believe that the ability of human tissue to regenerate will one day surpass that of salamanders. (Qjbio qjbio.com.cn)

  • Categories:Industry news
  • Author:
  • Origin:
  • Time of issue:2018-09-28
  • Views:93
Information

March 6, 2018 /Bio Valley BIOON/ -- Recently, in a study published in the international journal Cell, scientists from the Gladstone Institutes (Gladstone Institutes) A key gene for adult cell division and proliferation; some organisms have the ability to regenerate tissue remarkably. If fish and salamanders suffer heart damage, their cells will continue to divide and successfully repair damaged organs. Imagine if we also What would it be like to have this regenerative ability?

In the embryo, human heart cells can sort and proliferate to promote heart growth and development; but the problem is that right after birth, the body's cardiomyocytes lose the ability to divide, unlike many cells in other tissues of the body. The same, including the brain, spinal cord, and pancreas. Dr Deepak Srivastava explained that because many adult cells cannot divide, the body cannot replace the lost cells, which can lead to disease. If we can find a new way to make these cells divide again, then we may hope Achieving the regenerative capacity of a range of tissues.

Scientists have been trying to do this for decades, with little success; so far, these attempts have been ineffective and difficult to replicate; in this latest study, researchers may hope To achieve this ultimate goal, the researchers developed the first efficient and stable method to create adult cardiomyocytes that can divide and repair damaged heart tissue during a heart attack (at least in animal models). Of the more than 24 million patients with heart failure worldwide, there are few treatment options for patients other than heart transplants to treat patients with advanced disease; instead, cells divide to make new cardiomyocytes (similar to (like salamanders) may be able to help millions of patients repair damaged heart tissue.

Unlock the potential of adult cell reproduction

In this study, researchers Srivastava and colleagues identified four genes that control the cell division cycle. They found that when combined, these genes promote mature cardiomyocytes to re-enter the cell cycle, thereby causing Promotes cell division and rapid proliferation. "When the function of all four genes is increased simultaneously, adult cells begin to divide again and regenerate heart tissue," said researcher Tamer Mohamed. "We also found that when patients developed heart failure, combining these genes significantly improved the hearts of patients. Function.

The researchers then tested the new technique in animal models and in cardiomyocytes derived from human stem cells, using a rigorous technique to track whether these adult cells could actually make dividing cells that carry special colors that can be easily monitored. To divide in the heart, the results showed that in the mixed mode of the four genes, 15%-20% of the cardiomyocytes were able to divide and remain active.

Compared to previous findings (1%), this new technology may increase the efficiency and reliability of cell division. Of course, in human organs, gene application should be strictly monitored, because excessive or redundant cells Division often induces tumors; researchers will simplify the technique in later studies by finding ways to reduce the number of genes needed for cell division (while still maintaining the efficiency of cell division), and it turns out that using Two drug-like molecules to remove two of the genes yielded the same findings.

Regenerates a variety of human tissues

The researchers believe that this new technology may be used to induce other types of adult cells to divide again, and the four genes they used in the article are not unique to heart tissue; in the end, Srivastava said, heart cells are important to us. It's especially challenging because cardiomyocytes exit the cell cycle after an individual is born, and the cell's state is locked, which may explain why people don't develop heart tumors; The new technology for re-dividing these "difficult" cells may also be used in the future to "unlock" the potential of other types of cells to divide, including nerve cells, pancreatic cells, hair cells in the ear and retinal cells.

Based on the results of this paper, the researchers hope that through more in-depth research in the future, more powerful regenerative technologies can be developed to treat not only heart failure, but also many types of human diseases, including brain damage, diabetes, hearing loss and Blindness, etc.; researchers believe that the ability of human tissue to regenerate will one day surpass that of salamanders. (Qjbio qjbio.com.cn)

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