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HOMEProductSomatropin > Recombinant human growth hormone(Somatropin rDNA Origin)


A description of growth hormone

Growth hormone is a necessary protein produced by the pituitary gland in the hypothalamus of the brain. Growth hormone is the primary hormone responsible for the growth that occurs as a child matures into a full sized adult. Growth hormone plays an integral role in the metabolism of proteins, fats and carbohydrates, in people of all ages. Fully grown adults still require an adequate level of growth hormone for good health and correct body composition. Growth hormone will influence factors such as the ratio of good to bad cholesterol in the body, the ratio of lean muscle mass to fat and bone metabolism and promotion of healthy bone density throughout the full course of life. With insufficient levels of growth hormone, adults will experience poor metabolism, and an unhealthy body composition.

What is AGHD (adult growth hormone deficiency)?

Adults can experience a deficiency in growth hormone, and the health effects of this deficiency can be profound. Adults will experience a GH deficiency if their pituitary gland is not secreting an appropriate quantity of GH into the blood stream, or if through surgery or medical treatment, the pituitary is absent or underperforming. The pituitary is a vital gland, and is often named "the master gland" as the hormone secretions from the pituitary are responsible for the regulation and control of a number of different glands in the body. If an adult presents with an underperforming pituitary gland, it will be necessary to supplement the levels of the endogenous hormones with medical hormone supplements. One of the most important supplements in the treatment of a pituitary condition is supplementary growth hormone GH.

What are the causes of a growth hormone deficiency?

The primary causes of adult onset GH deficiency are surgery, accident trauma, disease of the hypothalamus or intra cranial radiation therapy.

GH deficient patients are usually segregated into two distinct groups. The first group comprises patients who were GH deficient as children, and continue to experience a GH deficiency, and the second group is adult onset GH deficiency.

Symptoms of growth hormone deficiency

People are not always aware of their GH deficiency, and the condition is under diagnosed. Some of the symptoms that may indicate a GH deficiency are:

 An unusual proportion of fat to lean muscle mass; GH deficient sufferers will have unusually high fat to muscle ratios, and will present especially with excess fat around the abdomen.

Heightened bad cholesterol levels can also be an indicator of a GH deficiency, as can changes in bone density. If you are very prone to breaking or fracturing bones, this could be a sign of a GH deficiency.

GH deficient patients show a reduced ability for exercise, and present with diminished stamina, diminished general energy levels, and reduced muscle strength. GH deficient patients may also suffer from a diminished psychological well being, and or feelings of social isolation.

These symptoms can present as symptoms for a number of disorders, but a GH deficiency should possibly be evaluated if you experience one or more of these symptoms.

Children who were GH deficient, but have since stopped growing, may or may not continue to be GH deficient, and should be tested for GH levels.

The test for GH deficiency is a standard growth hormone stimulation test. This test is used to diagnose both pediatric onset and adult onset GH deficiency. There are risks and side effects with GH treatment, and patients should be made aware of these risks and side effects, as to be able to make an informed decision as to whether GH treatment is right for them.

Why will I need to supplement my levels of GH

Even if you have finished growing, GH continues to play an important function in your body; and is essential for good health. If your doctor has determined that you are GH deficient, then your doctor will likely recommend supplementing your endogenous GH with a lab made GH supplement. GH is essential for correct metabolism, muscle to fat ratio promotion, and other important health factors. If you are GH deficient, GH treatment should greatly improve your affective health.

What is the replacement therapy for GH deficiency?

Replacement therapy for GH is no different from other hormone therapies. The primary goal of GH therapy is to restore the correct level of GH to the body for healthy and efficient metabolism and other processes.

Qitrope is used for the replacement of endogenous growth hormone in patients with biochemically confirmed AGHD (peak GH <5 ?g/L).

Patients must present with two criteria to be eligible for GH replacement treatment.

Firstly, the patient must show evidence of a GH deficiency on a GH stimulation test. Without a subnormal response to this test, GH therapy can not be initiated.

Additionally, if the condition is adult onset, the patient must also show evidence of a pituitary influencing condition such as, hypothalamus disease, intra cranial radiation, pituitary disease or trauma. If the GH deficiency began as child onset GH deficiency, the patient must confirm through a GH stimulation test administered as an adult, that there remains a need for GH treatment.

How is Qitrope administered?

Qitrope is an injectable hormone that should be injected into the fatty subcutaneous layer, directly below the skin. You should receive training from your health care team on the correct procedures for self injection, and on how best to inject Qitrope effectively, and safely.

Qitrope is a lyophilized powder formulation that is available in 3.33 mg vials. It is reconstituted, or mixed, with plain sterile water prior to an injection.

What are the storage requirements for Qitrope?

 You should however always store Qitrope in refriegerator between 2 - 8 degrees Celsius (35 - 46 Fahrenheit). Do not freeze it! Qitrope is light-sensitive and should be protected from light. Store the vials refrigerated in a dark place when they are not in use.

When mixed with water Qitrope is good for 20 days if properly refrigerated between 2 - 8 degrees Celsius (35 - 46 Fahrenheit).

Vials of Qitrope and diluent must be stored in the refrigerator at 2-8°C/36-46°F. After reconstitution, vial contents are stable for 14 days when stored in the refrigerator at 2-8°C/36-46°F.

You should never freeze human growth hormone. It is light-sensitive, so protect vials from light by storing them (refrigerated) in a dark place when you are not using them.






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