1

45

05

4

imgboxbg

Product center

Product center

Recombinant Human Growth Hormone (HGH) API

Ademetionine1,4-Butanedisulfonate (SAM)
Butylphthalide

imgboxbg

R & D

R & D

Technology Platform
Technology Team
Scientific Research Results

imgboxbg

Cooperation

Cooperation

News Center

News and information

10 2021-09

Qijian was invited to participate in "China Service Trade Fair 2021”

Our company was invited to participate in the "China Service Trade Fair 2021" which held in Beijing from September 4 to 7, 2021, Li Wei, Vice Governor of Jilin Province, visited Qijian 's booth, he encouraged us to strengthen exchanges and promote the development of service trade.
28 2018-09

New recombinant human growth hormone sustained-release microcapsules successfully developed

Recently, the Institute of Process Engineering, Chinese Academy of Sciences learned that a team led by Ma Guanghui, a researcher at the Institute, developed a recombinant human growth hormone sustained-release microcapsule with uniform particle size. The relevant results were published in the international academic journal Molecular Pharmacy. It is understood that recombinant human growth hormone (rhGH) is widely used in clinical treatment of short stature, severe burns, lipodystrophy in AIDS patients and other diseases. However, the half-life of rhGH is short, and frequent injections are required to achieve effective plasma concentrations, resulting in poor patient compliance. In response to this problem, scientists have conducted a lot of research on rhGH sustained-release microcapsules, but there are still common problems such as uneven particle size of microcapsules, unsustainable release, and poor drug stability. At the same time, the acidic products produced during the degradation of traditional hydrophobic material microcapsules can cause inflammation at the injection site and cause serious side effects. Therefore, the development of safe and effective rhGH sustained-release microcapsules has important research significance. This time, Ma Guanghui's team first used the W/O/W double emulsion method to load rhGH into the amphiphilic polylactic acid-polyethylene glycol copolymer emulsion, and combined with the rapid membrane emulsification technology to achieve the uniformity of the particle size of the microspheres . Subsequent in vivo rat model experiments show that the preparation can effectively prolong the release of rhGH in the body, and maintain the activity of rhGH well, and the rat bones grow significantly, which improves the therapeutic effect. In addition, compared with traditional polylactic acid (PLA) and polylactic acid-co-glycolic acid (PLGA) microcapsules, the preparation does not produce inflammatory reactions and has no effect on the functions of major organs such as the heart, liver, and kidneys. Safe sustained release carrier. The research work was supported by the "973" project and the National Natural Science Foundation of China.
28 2018-09

Cell: Breakthrough! Scientists identify key gene that is expected to promote cardiomyocyte regeneration to form heart tissue!

March 6, 2018 /Bio Valley BIOON/ -- Recently, in a study published in the international journal Cell, scientists from the Gladstone Institutes (Gladstone Institutes) A key gene for adult cell division and proliferation; some organisms have the ability to regenerate tissue remarkably. If fish and salamanders suffer heart damage, their cells will continue to divide and successfully repair damaged organs. Imagine if we also What would it be like to have this regenerative ability? In the embryo, human heart cells can sort and proliferate to promote heart growth and development; but the problem is that right after birth, the body's cardiomyocytes lose the ability to divide, unlike many cells in other tissues of the body. The same, including the brain, spinal cord, and pancreas. Dr Deepak Srivastava explained that because many adult cells cannot divide, the body cannot replace the lost cells, which can lead to disease. If we can find a new way to make these cells divide again, then we may hope Achieving the regenerative capacity of a range of tissues. Scientists have been trying to do this for decades, with little success; so far, these attempts have been ineffective and difficult to replicate; in this latest study, researchers may hope To achieve this ultimate goal, the researchers developed the first efficient and stable method to create adult cardiomyocytes that can divide and repair damaged heart tissue during a heart attack (at least in animal models). Of the more than 24 million patients with heart failure worldwide, there are few treatment options for patients other than heart transplants to treat patients with advanced disease; instead, cells divide to make new cardiomyocytes (similar to (like salamanders) may be able to help millions of patients repair damaged heart tissue. Unlock the potential of adult cell reproduction In this study, researchers Srivastava and colleagues identified four genes that control the cell division cycle. They found that when combined, these genes promote mature cardiomyocytes to re-enter the cell cycle, thereby causing Promotes cell division and rapid proliferation. "When the function of all four genes is increased simultaneously, adult cells begin to divide again and regenerate heart tissue," said researcher Tamer Mohamed. "We also found that when patients developed heart failure, combining these genes significantly improved the hearts of patients. Function. The researchers then tested the new technique in animal models and in cardiomyocytes derived from human stem cells, using a rigorous technique to track whether these adult cells could actually make dividing cells that carry special colors that can be easily monitored. To divide in the heart, the results showed that in the mixed mode of the four genes, 15%-20% of the cardiomyocytes were able to divide and remain active. Compared to previous findings (1%), this new technology may increase the efficiency and reliability of cell division. Of course, in human organs, gene application should be strictly monitored, because excessive or redundant cells Division often induces tumors; researchers will simplify the technique in later studies by finding ways to reduce the number of genes needed for cell division (while still maintaining the efficiency of cell division), and it turns out that using Two drug-like molecules to remove two of the genes yielded the same findings. Regenerates a variety of human tissues The researchers believe that this new technology may be used to induce other types of adult cells to divide again, and the four genes they used in the article are not unique to heart tissue; in the end, Srivastava said, heart cells are important to us. It's especially challenging because cardiomyocytes exit the cell cycle after an individual is born, and the cell's state is locked, which may explain why people don't develop heart tumors; The new technology for re-dividing these "difficult" cells may also be used in the future to "unlock" the potential of other types of cells to divide, including nerve cells, pancreatic cells, hair cells in the ear and retinal cells. Based on the results of this paper, the researchers hope that through more in-depth research in the future, more powerful regenerative technologies can be developed to treat not only heart failure, but also many types of human diseases, including brain damage, diabetes, hearing loss and Blindness, etc.; researchers believe that the ability of human tissue to regenerate will one day surpass that of salamanders. (Qjbio qjbio.com.cn)

About Us

About us

imgboxbg

Culture

Culture

imgboxbg

Honor

Honor

imgboxbg

Development

Development

imgboxbg

Enterprise Style

Enterprise Style

Contact Us

Contact us

Username used for comment:
客户留言
Description:
WeChat

WeChat

Contact Us

Contact Us

ADD: No.707 Chaofan street, High-Tech Industrial Development Zone, Changchun City, Jilin province, China
Service Hotline:0086-
431-81285900
Fax:0086-431-88794098
Email:
export@qijianbio.com

Copyright:Jilin Qijian Bio-pharmaceutical Co., Ltd.  by:300.cn  吉ICP备20003293号  SEO

搜索
Search