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Ademetionine 1,4-Butanedisulfonate(SAM)

Clinical literature
Chinese Pinyin
Ding’erhuangsuan Xiangandan’ansuan
Molecular formula
Molecular weight
White or off-white Powder

Ademetionine 1,4-Butanedisulfonate(SAM)

CAS: 101020-79-5

Molecular formula:C15H23N6O5S+

Formula weight:758.55
Brand: Qisam ®
Feature: safe effective, environmental protection, simple, mature technology & reliable

Category:White or off-white Powder

Qisam ® is made by Reorganization of the construction engineering bacteria,

with extraction of Phosphate solution, high purity enzyme was isolated, adenosine

methionine is prepared under the condition of easy purification and no side effect.



Liver disease





Packaging and specifications:


Tube vial for antibiotic use         



Or in aluminum foilbag, 



Storage: sealed  preservation, avoidsunlight ,storedin cool place


Exp.: 24 months



China National Standard

Corresponding parameter set not found, please add it in property template of background

A description of Adenosine methionine

SAM was discovered in the early 1950s. It’s made in the body from methionine, an amino acid found in foods. It has been found to regulate key functions in living cells.

Abnormal levels of SAM in the body have been reported in liver diseases and depression. This prompted researchers to investigate whether SAM might be helpful in treating these conditions. The idea that SAM might be helpful for osteoarthritis came from studies of SAM for depression. Some of the participants in the depression studies who also had osteoarthritis said their joint symptoms improved when they took SAM.

SAM helps maintain stable mood and joint function without side effects. In addition, SAM has multiple mechanisms of action that are used throughout the body, especially in the liver, which help maintain liver health. Largely known for its effects on optimal mood, SAM has also shown benefits for the liver, brain, and joints.

SAM is a naturally occurring compound found in every cell in the human body. This ubiquitous substance is involved in many critical biochemical pathways. Although regulated as a prescription drug in Europe, SAM is available in the US as a nutritional supplement. Extensive clinical research indicates that SAM is a safe and effective remedy for depression, osteoarthritis, and liver disease, providing powerful relief without the side effects commonly associated with prescription medications.

Safety and Side Effects of SAM

Information on the long-term safety of SAM is limited because the participants in most studies took it only for short periods of time. However, in one study of alcohol-related liver disease, participants took SAM for 2 years; in that study, no serious side effects were reported.

People with bipolar disorder (an illness characterized by mood swings, from depression to mania) should not take SAM for their depressive symptoms except under the supervision of a health care provider because SAM may worsen symptoms of mania.

Although SAM has been used to treat cholestasis during pregnancy, its safety during pregnancy has not been established.

SAM may decrease the effects of levodopa (L-dopa), a drug used to treat Parkinson’s disease. It’s also possible that SAM might interact with drugs and dietary supplements that increase levels of serotonin (a chemical produced by nerve cells), such as antidepressants, L-tryptophan, and St. John’s wort.

There’s a theoretical concern about the use of SAM by people who are immunocompromised (such as those who are HIV-positive). Immunocompromised people are at risk for Pneumocystis carinii infection, and SAM enhances the growth of this microorganism.

Side effects of SAM are uncommon, and when they do occur they are usually minor problems such as nausea or digestive upsets.